AGREE II: Advancing guideline development, reporting and evaluation in health care

Brouwers MC1, Kho ME, Browman GP, Burgers JS, Cluzeau F, Feder G, Fervers B, Graham ID, Grimshaw J, Hanna SE, Littlejohns P, Makarski J, Zitzelsberger L, AGREE Next Steps Consortium
CMAJ. 2010 Dec 14;182(18):E839-42

Clinical practice guidelines, which are systematically developed statements aimed at helping people make clinical, policy-related and system-related decisions frequently vary widely in quality. A strategy was needed to differentiate among guidelines and ensure that those of the highest quality are implemented.

An international team of guideline developers and researchers, known as the AGREE Collaboration (Appraisal of Guidelines, Research and Evaluation), was established to create a generic instrument to assess the process of guideline development and reporting of this process in the guideline. Based on rigorous methodologies, the result of the collaboration’s efforts was the original AGREE instrument, which is a 23-item tool comprising six quality-related domains that was released in 2003

As with any new assessment tool, ongoing development was required to improve its measurement properties, usefulness to a range of stakeholders and ease of implementation. Over the years, a number of issues were identified. For example, the original four-point response scale used to answer each item of the AGREEinstrument is not in compliance with methodologic standards of health measurement design. This noncompliance threatens the performance and reliability of the instrument. In addition, data on the usefulness of the AGREE items has never been gathered systematically from the perspectives of different groups of users. Further, we were interested in identifying strategies to make the evaluation process more efficient, such as reducing the number of items or the number of required raters, while ensuring the instrument was reliable and valid. Therefore, an exploration of the role of shorter versions of the AGREE instrument, comprising fewer items that are tailored to the unique priorities of different stakeholders, was warranted. Finally, there was a need to establish the fundamentals of construct validity — in other words, whether the AGREE items could measure what they purport to measure, and that is variability in quality of practice guidelines.


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